A.S.P.E.N. clinical guidelines: nutrition support of adult patients with hyperglycemia.
General
Guideline Title
A.S.P.E.N. clinical guidelines: nutrition support of adult patients with hyperglycemia.
Bibliographic Source(s)
- McMahon MM, Nystrom E, Braunschweig C, Miles J, Compher C, American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. clinical guidelines: nutrition support of adult patients with hyperglycemia. JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):23-36. [60 references] PubMed
Guideline Status
This is the current release of the guideline.
Recommendations
Major Recommendations
Definitions for the grading of recommendations ( Strong, Weak, Further Research Needed ) and levels of evidence ( High, Moderate, Low, Very Low ) are provided at the end of the “Major Recommendations” field.
What is the Desired Blood Glucose Goal Range in Adult Hospitalized Patients Receiving Nutrition Support?
The authors recommend a target blood glucose goal range of 140–180 mg/dL (7.8–10 mmol/L). ( Strong )
How is Hypoglycemia Defined in Adult Hospitalized Patients Receiving Nutrition Support?
The authors recommend that hypoglycemia be defined as a blood concentration of <70 mg/dL (<3.9 mmol/L). ( Strong )
Should Diabetes-Specific Enteral Formulas Be Used for Adult Hospitalized Patients With Hyperglycemia?
The authors cannot make a recommendation at this time. ( Further research needed )
Definitions:
Level of Evidence
High : Further research is very unlikely to change the authors’ confidence in the estimate of effect
Moderate : Further research is likely to have an important impact on the authors’ confidence in the estimate of effect and may change the estimate
Low : Further research is very likely to have an important impact on the authors’ confidence in the estimate of effect and is likely to change the estimate
Very Low : Any estimate of effect is very uncertain
Grade of Recommendation
Strong : Net benefits outweigh harms
Weak : Tradeoffs for patient are important
Further research needed : Uncertain tradeoffs
Clinical Algorithm(s)
None provided
Scope
Disease/Condition(s)
- Conditions or disease states requiring nutrition support
- Hyperglycemia
Guideline Category
- Diagnosis
- Evaluation
- Management
Clinical Specialty
- Critical Care
- Endocrinology
- Gastroenterology
- Geriatrics
- Nursing
- Nutrition
- Pharmacology
Intended Users
- Advanced Practice Nurses
- Allied Health Personnel
- Health Care Providers
- Hospitals
- Nurses
- Pharmacists
- Physician Assistants
- Physicians
Guideline Objective(s)
To summarize the most current evidence and provides guidelines for the desired blood glucose goal range in hospitalized patients receiving nutrition support, the definition of hypoglycemia, and the rationale for use of diabetes-specific enteral formulas in hospitalized patients
Note : This guideline does not address other specific strategies for managing hyperglycemia in patients receiving nutrition support, as there are little to no data to support clinical practice recommendations in this area.
Target Population
Adult hospitalized patients receiving nutrition support
Interventions and Practices Considered
- Target blood glucose goals
- Criteria for defining hypoglycemia in hospitalized patients receiving nutrition support
- Diabetes specific enteral formulas for adult patients with hyperglycemia (considered but not recommended).
Major Outcomes Considered
- Mortality
- Adverse outcomes associated with hyperglycemia
- Glycemic and lipid control
Methodology
Methods Used to Collect/Select the Evidence
- Searches of Electronic Databases
Description of Methods Used to Collect/Select the Evidence
For the current Clinical Guideline, inclusion criteria of adult subjects, complication of hyperglycemia, and hospital setting were used. Search terms of diabetes mellitus, hyperglycemia, hypoglycemia, clinical outcomes, parenteral nutrition, and enteral nutrition were applied in various combinations to CENTRAL (The Cochrane Library), MEDLINE, EMBASE, Science Citation Index Expanded, LILACS, and CINAHL (until December 2011).
Number of Source Documents
Not stated
Methods Used to Assess the Quality and Strength of the Evidence
- Weighting According to a Rating Scheme (Scheme Given)
Rating Scheme for the Strength of the Evidence
Level of Evidence
High: Further research is very unlikely to change the authors' confidence in the estimate of effect
Moderate: Further research is likely to have an important impact on the authors' confidence in the estimate of effect and may change the estimate
Low: Further research is very likely to have an important impact on the authors' confidence in the estimate of effect and is likely to change the estimate
Very Low: Any estimate of effect is very uncertain
Methods Used to Analyze the Evidence
- Systematic Review with Evidence Tables
Description of the Methods Used to Analyze the Evidence
A systematic review of the best available evidence to answer a series of questions regarding glucose control in adults receiving parenteral or enteral nutrition was undertaken and evaluated using concepts adopted from the Grading of Recommendations, Assessment, Development and Evaluation working group.
Methods Used to Formulate the Recommendations
- Expert Consensus
Description of Methods Used to Formulate the Recommendations
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Clinical Guidelines have adopted concepts of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) working group. Briefly, specific clinical questions where nutrition support is a relevant mode of therapy are developed and key clinical outcomes are identified. A rigorous search of the published literature is conducted, each included study assessed for research quality, tables of findings developed, the body of evidence for the question evaluated, and a recommendation for clinical practice that is based on both the best available evidence and the risks and benefits to patients developed by consensus. Recommendations are graded as strong when the evidence is strong and/or net benefits outweigh harms. Weak recommendations may be based on weaker evidence and/or important trade-offs to the patient. When limited research is available to answer a question, no recommendation can be made.
Rating Scheme for the Strength of the Recommendations
Grade of Recommendation
Strong : Net benefits outweigh harms
Weak : Tradeoffs for patient are important
Further research needed : Uncertain tradeoffs
Cost Analysis
A cost analysis was not performed and published cost analyses were not reviewed.
Method of Guideline Validation
- External Peer Review
- Internal Peer Review
Description of Method of Guideline Validation
A consensus process was used to develop the clinical guideline recommendations prior to external and internal review and approval by the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors.
Evidence Supporting the Recommendations
Type of Evidence Supporting the Recommendations
The type of supporting evidence ranges from prospective randomized trials to expert opinion/consensus.
Benefits/Harms of Implementing the Guideline Recommendations
Potential Benefits
In hospitalized patients receiving nutrition support:
- Reduction in adverse outcomes due to hyperglycemia
- Improvement in assessment (definition/target range) of blood glucose control
Potential Harms
Both hyperglycemia and hypoglycemia (resulting from attempts to correct hyperglycemia) are associated with adverse outcomes in diabetic as well as nondiabetic patients.
Qualifying Statements
Qualifying Statements
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Clinical Guidelines are based on general conclusions of health professionals who, in developing such guidelines, have balanced potential benefits to be derived from a particular mode of medical therapy against certain risks inherent with such therapy. However, the professional judgment of the attending health professional is the primary component of quality medical care. Because guidelines cannot account for every variation in circumstances, the practitioner must always exercise professional judgment in their application. These Clinical Guidelines are intended to supplement, but not replace, professional training and judgment.
Implementation of the Guideline
Description of Implementation Strategy
An implementation strategy was not provided.
Implementation Tools
- Resources
Institute of Medicine (IOM) National Healthcare Quality Report Categories
IOM Care Need
- Getting Better
- Living with Illness
IOM Domain
- Effectiveness
Identifying Information and Availability
Bibliographic Source(s)
- McMahon MM, Nystrom E, Braunschweig C, Miles J, Compher C, American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. clinical guidelines: nutrition support of adult patients with hyperglycemia. JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):23-36. [60 references] PubMed
Adaptation
Not applicable: The guideline was not adapted from another source.
Date Released
2013 Jan
Guideline Developer(s)
- American Society for Parenteral and Enteral Nutrition - Professional Association
Source(s) of Funding
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Guideline Committee
Not stated
Composition of Group That Authored the Guideline
Authors : M. Molly McMahon, MD; Erin Nystrom, PharmD, BCNSP; Carol Braunschweig, PhD, RD; John Miles, MD; Charlene Compher, PhD, RD, CNSC, LDN, FADA; American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Financial Disclosures/Conflicts of Interest
Financial disclosure: none declared
Guideline Status
This is the current release of the guideline.
Guideline Availability
Electronic copies: Available from the Journal of Parenteral and Enteral Nutrition Web site.
Availability of Companion Documents
The following is available:
- Clinical guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients: applying the GRADE system to development of A.S.P.E.N. clinical guidelines. American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). 2012 Jan. 5 p. Electronic copies: Available from the Journal of Parenteral and Enteral Nutrition Web site.
Patient Resources
None available
NGC Status
This NGC summary was completed by ECRI Institute on December 27, 2012. The information was verified by the guideline developer on January 21, 2013.
Copyright Statement
This NGC summary is based on the original guideline, which is subject to the guideline developer’s copyright restrictions.
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