Best evidence statement (BESt). Physical therapy during the hemopoietic stem cell transplant process to improve quality of life.
General
Guideline Title
Best evidence statement (BESt). Physical therapy during the hemopoietic stem cell transplant process to improve quality of life.
Bibliographic Source(s)
- Cincinnati Children’s Hospital Medical Center. Best evidence statement (BESt). Physical therapy during the hemopoietic stem cell transplant process to improve quality of life. Cincinnati (OH): Cincinnati Children’s Hospital Medical Center; 2014 Mar 18. 9 p. [17 references]
Guideline Status
This is the current release of the guideline.
Recommendations
Major Recommendations
The strength of the recommendation (strongly recommended, recommended, or no recommendation) and the quality of the evidence (1a‒5b) are defined at the end of the “Major Recommendations” field.
- It is strongly recommended that physical therapists provide exercise therapy, including endurance and strength training, throughout the hemopoietic stem cell transplant (HSCT) process to reduce/minimize the effects of immobility and consequences of the HSCT treatment, which contributes to improved quality of life (QoL) (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Baumann et al., 2011 [2b]; Hacker et al., 2011 [2b]; Baumann et al., 2010 [2b]; Hayes et al., 2004).
Note 1 : Side effects of immunosuppressive therapy and bed rest can include loss of muscle mass, strength and endurance (Wolin et al., 2010 [1a]; Knols et al., 2005 [1a]; Wiskemann & Huber, 2008 [1b]; Baumann et al., 2011 [2b]).
Note 2 : Pediatric patients benefitted from frequent, supervised intervention, suggesting the need for higher frequency to achieve desired outcomes (Wolin et al., 2010 [1a]).
Note 3 : Full recovery from HSCT is a 3 to 5 year process. Recovery may be accelerated by exercise interventions to increase work related capabilities, improve social support and manage depression (Syrjala et al., 2004 [4a]).
- It is recommended that a physical therapist provide the following interventions in the pre-transplant phase: 1. Complete a physical therapy examination to establish a baseline level of function and QoL (Local Consensus, 2013 [5]). 2. Make recommendations for treatment (based upon) specific to the evaluation results, as appropriate (Wiskemann et al., 2011 [2b]; Local Consensus, 2013 [5]). 3. Educate families regarding the benefits of structured exercise therapy throughout the HSCT process to reduce the effects of immobility and consequences of the HSCT treatment (Local Consensus, 2013 [5]).
Note 1 : It is preferred the physical therapy examination be completed, including assessments of strength, endurance and QoL, prior to the initiation of the preparative regimen and inpatient admission for HSCT in order to obtain an accurate baseline measurement and identify needs for physical therapy intervention (Wiskemann et al., 2011 [2b]; Local Consensus, 2013 [5]).
Note 2 : Caregiver and patient education should be provided using appropriate methods including, but not limited to instructional materials or 1:1 educational sessions (Local Consensus, 2013 [5]).
- It is strongly recommended that during the HSCT inpatient stay, starting at admission or the initiation of the preparative treatment regimen and continuing until discharge, a physical therapist provide a supervised, low to moderate intensity exercise program to positively affect QoL, including: 1. Aerobic endurance training (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Knols et al., 2011 [2a]; Baumann et al., 2011 [2b]; Baumann et al., 2010 [2b]; Jarden et al., 2009 [2b]; Jarden et al., 2007 [2b]) 2. Exercises dealing with strength, balance/coordination and flexibility (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Knols et al., 2011 [2a]; Baumann et al., 2011 [2b]; Baumann et al., 2010 [2b]; Jarden et al., 2009 [2b]; Jarden et al., 2007 [2b])
Note 1 : During the inpatient stay for HSCT, the risk of infection is high and physical activity options may be restricted, therefore equipment and exercise options may be reduced (Wolin et al., 2010 [1a]; Local Consensus, 2013 [5]).
Note 2 : A higher frequency exercise program (i.e., 5 times per week or daily) is beneficial in stabilizing physical performance (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Jarden et al., 2009 [2b]).
Note 3 : A low to moderate intensity exercise program for 30 to 60 minutes (with rest intervals as needed) may include:
1. Aerobic exercise at 50% to 75% of the heart rate max and a rate of perceived exertion (RPE) of 10 to 13
2. Strengthening/stretching exercises at an RPE of 10 to 13
3. Progressive relaxation exercises at an RPE of 6 to 9 (Jarden et al., 2009 [2b]; Local Consensus, 2013 [5]) 4. It is recommended that during the HSCT inpatient stay, a physical therapist provide interventions to promote functional mobility, including transfers, walking and stair climbing (Baumann et al., 2011 [2b]; Local Consensus, 2013 [5]) and relaxation through progressive relaxation exercises (Jarden et al., 2009 [2b]; Jarden et al., 2007 [2b]). 5. It is strongly recommended that following discharge from the HSCT inpatient stay, a physical therapist provide a supervised, scheduled moderate intensity exercise program (with the goal to return the individual to functional baseline level or until progress is no longer demonstrated) including the following:
1. Aerobic endurance training (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Knols et al., 2011 [2a]; Wiskemann et al., 2011 [2b])
2. Exercises dealing with strength, balance/coordination and flexibility (Wolin et al., 2010 [1a]; Wiskemann & Huber, 2008 [1b]; Knols et al., 2011 [2a]; Wiskemann et al., 2011 [2b])
Note 1 : The exercise program is designed to reduce fatigue, improve physical function and positively affect QoL (Wiskemann et al., 2011 [2b]).
Note 2 : A minimum frequency and duration (i.e., 2x/week for 6 to 12 weeks) may be beneficial at this stage of recovery (Knols et al., 2005 [1a]; Local Consensus, 2013 [5]; Hayes et al., 2004).
Note 3 : A moderate intensity exercise program for 30 to 60 minutes may include:
1. Aerobic exercise starting at 50% to 60% and increasing up to 70% to 80% of the heart rate max and a RPE up to 15
2. Strengthening/stretching exercises at an RPE of 10 to 13 (Knols et al., 2011 [2a]; Local Consensus, 2013 [5]) 6. It is recommended that during outpatient program following HSCT a physical therapist provide interventions to promote functional mobility, including transfers, walking and stair climbing (Knols et al., 2011 [2a]; Local Consensus, 2013 [5]).
Definitions:
Table of Evidence Levels
Quality Level | Definition |
---|---|
1a† or 1b† | Systematic review, meta-analysis, or meta-synthesis of multiple studies |
2a or 2b | Best study design for domain |
3a or 3b | Fair study design for domain |
4a or 4b | Weak study design for domain |
5a or 5b | General review, expert opinion, case report, consensus report, or guideline |
5 | Local Consensus |
†a = good quality study; b = lesser quality study.
Table of Language and Definitions for Recommendation Strength
Strength | Definition |
---|---|
It is strongly recommended that…
It is strongly recommended that… not… |
When the dimensions for judging the strength of the evidence are applied, there is high support that benefits clearly outweigh risks and burdens (or vice-versa for negative recommendations). |
It is recommended that…
It is recommended that… not… |
When the dimensions for judging the strength of the evidence are applied, there is moderate support that benefits are closely balanced with risks and burdens. |
There is insufficient evidence and a lack of consensus to make a recommendation… |
Note : See the original guideline document for the dimensions used for judging the strength of the recommendation.
Clinical Algorithm(s)
None provided
Scope
Disease/Condition(s)
Diseases/conditions requiring hemopoietic stem cell transplant (HSCT)
Guideline Category
- Management
- Treatment
Clinical Specialty
- Oncology
- Pediatrics
- Physical Medicine and Rehabilitation
Intended Users
- Advanced Practice Nurses
- Physical Therapists
- Physician Assistants
- Physicians
Guideline Objective(s)
To evaluate, among school aged children and adolescents receiving hemopoietic stem cell transplant (HSCT), if physical therapy (PT) intervention (active participation in mobility, endurance, strength exercise) compared to no intervention improves the patient’s quality of life (QoL)
Target Population
School aged children, adolescents and young adults age 6 to 21 years receiving hemopoietic stem cell transplant (HSCT) (during both inpatient and outpatient phases)
Note : This guideline does not apply to individuals unable to cognitively participate (unable to follow commands or instructions) in a structured exercise program.
Interventions and Practices Considered
Physical therapy (PT) (active participation in mobility, endurance, strength exercise)
Major Outcomes Considered
Improvement of patient quality of life (QoL)
Methodology
Methods Used to Collect/Select the Evidence
- Searches of Electronic Databases
Description of Methods Used to Collect/Select the Evidence
Search Strategy
- Databases : Trip, PubMed Clinical Queries, Pediatric Physical Therapy, EBSCO, CINAHL Plus with full text, PEDro, MEDLINE, CINAHL, Cochrane, CAOT, OT Seeker, OTEvidence, Center for Evidence Based Medicine, National Guideline Clearinghouse (NGC), Google Scholar, Rehabilitative Reference Center, Cochrane library
- Search Terms : exercise, bone marrow transplant, stem cell transplant, children, pediatric, childhood, physical therapy, quality of life, pediatric, cancer, physical activity, bone marrow transplant + physical therapy, bone marrow transplant + rehabilitation, bone marrow transplant + child + rehabilitation, bone marrow transplant + quality of life , brain tumors, therapy, occupational therapy, autologous bone marrow transplant, fatigue + bone marrow transplant, daily living + bone marrow transplant, self-care + bone marrow transplant
- Limits and Filters : Limits and filters were applied randomly to individual databases by multiple people participating in the search. Those include: 2000 to 2011, pediatrics.
- Last Search Date : December 2013
Number of Source Documents
Not stated
Methods Used to Assess the Quality and Strength of the Evidence
- Weighting According to a Rating Scheme (Scheme Given)
Rating Scheme for the Strength of the Evidence
Table of Evidence Levels
Quality Level | Definition |
---|---|
1a† or 1b† | Systematic review, meta-analysis, or meta-synthesis of multiple studies |
2a or 2b | Best study design for domain |
3a or 3b | Fair study design for domain |
4a or 4b | Weak study design for domain |
5a or 5b | General review, expert opinion, case report, consensus report, or guideline |
5 | Local Consensus |
†a = good quality study; b = lesser quality study.
Methods Used to Analyze the Evidence
- Systematic Review
Description of the Methods Used to Analyze the Evidence
Not stated
Methods Used to Formulate the Recommendations
- Expert Consensus
Description of Methods Used to Formulate the Recommendations
Not stated
Rating Scheme for the Strength of the Recommendations
Table of Language and Definitions for Recommendation Strength
Strength | Definition |
---|---|
It is strongly recommended that… It is strongly recommended that… not… | When the dimensions for judging the strength of the evidence are applied, there is high support that benefits clearly outweigh risks and burdens (or vice-versa for negative recommendations). |
It is recommended that… It is recommended that… not… | When the dimensions for judging the strength of the evidence are applied, there is moderate support that benefits are closely balanced with risks and burdens. |
There is insufficient evidence and a lack of consensus to make a recommendation… |
Note : See the original guideline document for the dimensions used for judging the strength of the recommendation.
Cost Analysis
A formal cost analysis was not performed and published cost analyses were not reviewed.
Method of Guideline Validation
- Peer Review
Description of Method of Guideline Validation
This Best Evidence Statement (BESt) has been reviewed against quality criteria by two independent reviewers from the Cincinnati Children’s Hospital Medical Center (CCHMC) Evidence Collaboration.
Evidence Supporting the Recommendations
References Supporting the Recommendations
- Baumann FT, Kraut L, Schüle K, Bloch W, Fauser AA. A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant. 2010 Feb;45(2):355-62. PubMed
- Baumann FT, Zopf EM, Nykamp E, Kraut L, Schüle K, Elter T, Fauser AA, Bloch W. Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention. Eur J Haematol. 2011 Aug;87(2):148-56. PubMed
- Hacker ED, Larson J, Kujath A, Peace D, Rondelli D, Gaston L. Strength training following hematopoietic stem cell transplantation. Cancer Nurs. 2011 May-Jun;34(3):238-49. PubMed
- Hayes S, Davies PS, Parker T, Bashford J, Newman B. Quality of life changes following peripheral blood stem cell transplantation and participation in a mixed-type, moderate-intensity, exercise program. Bone Marrow Transplant. 2004 Mar;33(5):553-8. PubMed
- Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L. A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant. 2009 May;43(9):725-37. PubMed
- Jarden M, Hovgaard D, Boesen E, Quist M, Adamsen L. Pilot study of a multimodal intervention: mixed-type exercise and psychoeducation in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant. 2007 Oct;40(8):793-800. PubMed
- Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol. 2005 Jun 1;23(16):3830-42. PubMed
- Knols RH, de Bruin ED, Uebelhart D, Aufdemkampe G, Schanz U, Stenner-Liewen F, Hitz F, Taverna C, Aaronson NK. Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: a randomized clinical trial. Bone Marrow Transplant. 2011 Sep;46(9):1245-55. PubMed
- Syrjala KL, Langer SL, Abrams JR, Storer B, Sanders JE, Flowers ME, Martin PJ. Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA. 2004 May 19;291(19):2335-43. PubMed
- Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, Ulrich CM, Bohus M. Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood. 2011 Mar 3;117(9):2604-13. PubMed
- Wiskemann J, Huber G. Physical exercise as adjuvant therapy for patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Feb;41(4):321-9. PubMed
- Wolin KY, Ruiz JR, Tuchman H, Lucia A. Exercise in adult and pediatric hematological cancer survivors: an intervention review. Leukemia. 2010 Jun;24(6):1113-20. PubMed
Type of Evidence Supporting the Recommendations
The type of supporting evidence is identified and graded for each recommendation (see the “Major Recommendations” field).
Benefits/Harms of Implementing the Guideline Recommendations
Potential Benefits
Trends suggest physical therapy (PT) intervention (active participation in mobility, endurance, strength exercise) during hemopoietic stem cell transplant (HSCT) hospitalization to be feasible, safe, well tolerated and of possible benefit to quality of life (QoL)
Potential Harms
Not stated
Qualifying Statements
Qualifying Statements
This Best Evidence Statement addresses only key points of care for the target population; it is not intended to be a comprehensive practice guideline. These recommendations result from review of literature and practices current at the time of their formulation. This Best Evidence Statement does not preclude using care modalities proven efficacious in studies published subsequent to the current revision of this document. This document is not intended to impose standards of care preventing selective variances from the recommendations to meet the specific and unique requirements of individual patients. Adherence to this Statement is voluntary. The clinician in light of the individual circumstances presented by the patient must make the ultimate judgment regarding the priority of any specific procedure.
Implementation of the Guideline
Description of Implementation Strategy
Applicability Issues
Hemopoietic stem cell transplant (HSCT) patients need to be identified early by members of the health care team in order to facilitate referral for physical therapy (PT) evaluation of appropriate patients in the pre-HSCT phase. Hindrances to early referral may include patient geographic location, medical status and schedule conflicts within the HSCT work-up.
Exercise intervention should be provided by physical therapists who have knowledge of the HSCT process. Additional staffing resources need to be identified, to cover the demands for high utilization of therapy resources.
Collaboration and planning is required to expedite management of patient care across inpatient and outpatient settings, including appropriate notification, referral and sharing of information by inpatient and outpatient physical therapists.
Implementation Tools
- Audit Criteria/Indicators
Institute of Medicine (IOM) National Healthcare Quality Report Categories
IOM Care Need
- Getting Better
- Living with Illness
IOM Domain
- Effectiveness
- Patient-centeredness
Identifying Information and Availability
Bibliographic Source(s)
- Cincinnati Children’s Hospital Medical Center. Best evidence statement (BESt). Physical therapy during the hemopoietic stem cell transplant process to improve quality of life. Cincinnati (OH): Cincinnati Children’s Hospital Medical Center; 2014 Mar 18. 9 p. [17 references]
Adaptation
Not applicable: The guideline was not adapted from another source.
Date Released
2014 Mar 18
Guideline Developer(s)
- Cincinnati Children’s Hospital Medical Center - Hospital/Medical Center
Source(s) of Funding
Cincinnati Children’s Hospital Medical Center
No external funding was received for development of this Best Evidence Statement (BESt).
Guideline Committee
Not stated
Composition of Group That Authored the Guideline
Team Leader/Author : Mariann L. Strenk PT, DPT, MHS, Team Leader, Division of Occupational Therapy and Physical Therapy
Team Members : Andrea Gevedon, PT, DPT, Division of Occupational Therapy and Physical Therapy; Jessica Monfreda, PT, DPT, Division of Occupational Therapy and Physical Therapy
Ad hoc Advisors : Michelle Kiger, OTR/L, Division of Occupational Therapy and Physical Therapy; Karen Vonderhaar, MS, RN, Guidelines Program Administrator; James M. Anderson Center for Health Systems Support
Other BESt Development Support : Mary Gilene, MBA, Division of Occupational Therapy and Physical Therapy
Content Reviewers : Stella M. Davies, MBBS PhD, Bone Marrow Transplantation & Immune Deficiency
Financial Disclosures/Conflicts of Interest
Conflict of interest declaration forms are filed with the Cincinnati Children’s Hospital Medical Center (CCHMC) Evidence-Based Decision Making (EBDM) group. No financial conflicts of interest were found.
Guideline Status
This is the current release of the guideline.
Guideline Availability
Available from the Cincinnati Children’s Hospital Medical Web site.
Availability of Companion Documents
The following are available:
- Judging the strength of a recommendation. Cincinnati (OH): Cincinnati Children’s Hospital Medical Center; 2008 Jan. 1 p. Available from the Cincinnati Children’s Hospital Medical Center.
- Grading a body of evidence to answer a clinical question. Cincinnati (OH): Cincinnati Children’s Hospital Medical Center; 1 p.
- Table of evidence levels. Cincinnati (OH): Cincinnati Children’s Hospital Medical Center; 2008 Feb 29. 1 p. Available from the Cincinnati Children’s Hospital Medical Center.
In addition, suggested process or outcome measures are available in the original guideline document.
Patient Resources
None available
NGC Status
This NGC summary was completed by ECRI Institute on June 18, 2014.
Copyright Statement
This NGC summary is based on the original full-text guideline, which is subject to the following copyright restrictions:
Copies of this Cincinnati Children’s Hospital Medical Center (CCHMC) Best Evidence Statement (BESt) are available online and may be distributed by any organization for the global purpose of improving child health outcomes. Examples of approved uses of the BESt include the following:
- Copies may be provided to anyone involved in the organization’s process for developing and implementing evidence based care.
- Hyperlinks to the CCHMC Web site may be placed on the organization’s Web site.
- The BESt may be adopted or adapted for use within the organization, provided that CCHMC receives appropriate attribution on all written or electronic documents.
- Copies may be provided to patients and the clinicians who manage their care.
Notification of CCHMC at EBDMInfo@cchmc.org for any BESt adopted, adapted, implemented or hyperlinked by the organization is appreciated.
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